Meneguzzo began his artistic path as a painter and sculptor, later expanding into ceramics in 1949 while working at the “La Freccia” workshop of Tarcisio Tosin. His early recognition came with a solo exhibition in 1953 at the Galleria del Calibano in Vicenza. The following year he moved to Milan, where he worked as a decorator and set designer for Rai.

In Milan, his activity in ceramics intensified: in 1955 he co-founded, together with Bruno Danese, the workshop “DEM,” dedicated to artistic ceramic production. After its closure in 1957, he continued collaborating with Danese at “Danese Ceramiche” until 1963. Alongside this work, he exhibited in Milan at the Ariete Gallery in 1956 and later held a solo show at Galleria Il Milione, also participating in 1962 in the International Exhibition of Contemporary Ceramics in Prague.

From the early 1960s, his focus gradually shifted away from ceramics toward painting and sculpture, fields in which he established himself as a significant figure in Italian Informal art.